Edexcel IGCSE Human Biology Past Papers
GradeMax provides comprehensive IGCSE Human Biology revision with real past paper questions organised by chapter. Practice cells & tissues, biological molecules, coordination, nutrition, respiration, internal transport, homeostasis, and reproduction with full mark schemes.
15 years of papers (2011–2025) · 12 topics · Mark schemes included · Free download
IGCSE Human Biology Topics
Practice topic-wise Edexcel IGCSE Human Biology past paper questions with mark schemes
Cells and tissues
Cell ultrastructure, DNA structure and replication, protein synthesis, mitosis, stem cells, tissue and organ organisation, genetic engineering.
Biological molecules
Structure of carbohydrates, proteins and lipids; food tests (Benedict's, iodine, Biuret); enzyme action and kinetics; immobilised enzymes.
Movement of substances in and out of cells
Diffusion, osmosis and water potential, active transport, surface area to volume ratio.
Bones, muscles and joints
Axial and appendicular skeleton, bone structure, synovial joints, antagonistic muscle action, osteoporosis.
Coordination
Nervous system, nerve impulses and synapses, reflex arc, endocrine system, eye, ear, drugs and their effects, mental illness, neurodegenerative diseases.
Nutrition and energy
Balanced diet, deficiency diseases, digestive system, enzymes in digestion, absorption in small intestine, dental health, obesity.
Respiration
Aerobic and anaerobic respiration, ATP and energy transfer, oxygen debt.
Gas exchange
Ventilation mechanism, gas exchange in alveoli, lung volumes, exercise and cardiovascular response, effects of smoking.
Internal transport
Blood composition, blood vessels, heart structure and function, cardiovascular disease, blood pressure, monoclonal antibodies.
Homeostatic mechanisms
Homeostasis and negative feedback, temperature regulation, kidney structure and function, osmoregulation, blood glucose regulation, liver.
Reproduction and heredity
Meiosis, reproductive systems, menstrual cycle, pregnancy, contraception, IVF, genetics and inheritance, inherited conditions, gene therapy.
Health, disease and immunity
Types of disease, pathogens, disease transmission, immune response, phagocytosis, antibodies, vaccination, antibiotics and resistance, cancer.
IGCSE Human Biology Past Papers by Year
IGCSE Human Biology — Frequently Asked Questions
What topics are in Edexcel IGCSE Human Biology (4HB1)?
Edexcel IGCSE Human Biology has 12 chapters: Cells and tissues, Biological molecules, Movement of substances, Bones and muscles, Coordination, Nutrition and energy, Respiration, Gas exchange, Internal transport, Homeostatic mechanisms, Reproduction and heredity, and Health, disease and immunity.
How many papers are in IGCSE Human Biology?
Edexcel IGCSE Human Biology has two papers: Paper 1 (4HB1/01) and Paper 2 (4HB1/02), each worth 50%, lasting 1 hour 45 minutes, and marked out of 90.
What is the difference between mitosis and meiosis in IGCSE Human Biology?
Mitosis produces 2 identical diploid cells for growth and repair. Meiosis produces 4 genetically different haploid cells (gametes — sperm and eggs) for sexual reproduction. Meiosis creates genetic variation through crossing over and independent assortment.
What years of IGCSE Human Biology past papers are available?
GradeMax provides Edexcel IGCSE Human Biology past papers from 2011 to 2025, covering both Paper 1 and Paper 2 with mark schemes.